Sialyl Lewis X mimetics incorporating mannopeptides

US5837862A · kind A · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Chi-Huey Wong · Village of La Jolla, US
• Thomas G. Marron · Grayslake, US
• Thomas Woltering · Freiburg (Elbe), DE
• Gabriele Weitz-Schmidt · Bad Krozingen, DE

Key dates

• Filing date: Dec 12, 1996
• Grant date: Nov 17, 1998
• Expiry date: Dec 12, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Sialyl Lewis X mimetics based on mannose glycosides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The mannose based mimetics exhibit comparable biological activity as sialyl Lewis X in the E- selectin binding assay and can be employed for blocking neutrophil inflamatory conditions.