Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use

US5840686A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Gerald Chader · Bethesda, US
• Sofia Patricia Becerra · Bethesda, US
• Joan P. Schwartz · Bethesda, US
• Takayuki Taniwaki · Koga, JP
• Yukihiro Sugita · Rockville, US

Key dates

• Filing date: Jun 7, 1994
• Grant date: Nov 24, 1998
• Expiry date: Jun 7, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF -BP, -BX and BA, and the PEDF protein produced by recombinant methods Effects and uses of these variants on 1) neuronal differentiation (neurotrophic effect) 2) neuron survival (neuronotrophic effect) and 3) glial inhibition (gliastatic effect) are described.