Assay method for screening for inhibitors of proTNF conversion
US5843693A · kind A · utility
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2Claims
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Key dates
| Filing date | Feb 27, 1995 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Feb 27, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/811
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature, active TNF.alpha.. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF.alpha. to its mature active form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.