Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
US5849927A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 10, 1997 |
| Grant date | Dec 15, 1998 |
| Priority date | — |
| Expiry date | Jun 10, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds of the formula: ##STR1## wherein: T is NH, O, or S; PA1 X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide; PA1 the W ring is an optionally substituted aryl or heteroaryl group; and ##STR2## represents an optionally substituted benzo group or an optionally substituted 5, 6, 7, or 8 membered ring. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.