Azetidine, pyrrolidine and piperidine derivatives
US5854268A · kind A · utility
Assignee
Inventors
- Raymond Baker
- Sylvie Bourrain
- Jose Luis Castro Pineiro
- Mark Stuart Chambers
- Alexander Richard Guiblin
- Sarah Christine Hobbs
- Richard Alexander Jelley
- Andrew Madin
- Victor Giulio Matassa
- Austin John Reeve
- Michael Geoffrey Neil Russell
- Graham Andrew Showell
- Francine Sternfeld
- Leslie Joseph Street
- Monique Bodil Van Niel
Key dates
| Filing date | Jan 22, 1997 |
| Grant date | Dec 29, 1998 |
| Priority date | — |
| Expiry date | Jan 22, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.