Calanolide and related antiviral compounds, compositions, and uses thereof

US5859049A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• The Board of Trustees of the University of Illinois · US

Inventors

• Michael R. Boyd · Mobile, US
• John H. Cardellina, II · Fort Detrick, US
• Kirk R. Gustafson · Frederick, US
• James B. McMahon · Frederick, US
• Richard W. Fuller · Fairfield, US
• Gordon M. Cragg · Bethesda, US
• Yoel Kashman · Nes Ziona, IL
• Doel Soejarto · Lombard, US

Key dates

• Filing date: May 24, 1996
• Grant date: Jan 12, 1999
• Expiry date: May 24, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.