Acetylsalicylic acid nitrates

US5859053A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eva Lesur · Neunburg vorm Wald, DE
• Dieter Neuser · Langenfeld, DE
• Oswald Lockhoff · Cologne, DE
• Elisabeth Perzborn · Wuppertal, DE
• Peter Kurka · Langenfeld, DE
• Johannes-Peter Stasch · Wuppertal, DE

Key dates

• Filing date: Oct 24, 1997
• Grant date: Jan 12, 1999
• Expiry date: Oct 24, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new derivatives of acetylsalicylic acid (called ASA in the following), which contain an NO.sub.3 structure. They are therapeutically active either as the intact active compound molecule or after cleavage (NO release). The invention also relates to processes for their preparation and their use as medicaments, in particular for the alleviation of pain, inhibition of platelet aggregation, lowering of fever and for the prevention of cardiovascular disorders and oncoses.