Patent · US Expired

Process for the synthesis of 2'-O-substituted pyrimidines

US5861493A · kind A · utility

10Cited by

4References

12Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Phillip Dan Cook · Carlsbad, US
Robert H. Springer · Wyckoff, US
Kelly G. Sprankle · Vista, US
Bruce Ross · Carlsbad, US

Key dates

Filing date	Jul 9, 1997
Grant date	Jan 19, 1999
Priority date	—
Expiry date	Jul 9, 2017

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/582
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.