Substituted ketone derivatives as inhibitors of interleukin-1.beta. converting enzyme
US5866545A · kind A · utility
14Cited by
6References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 11, 1996 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Jan 11, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to substituted ketone derivatives of formula (I) useful in the treatment of inflammation in lung, central nervous system, kidney, joints, endocardium, pericardium, eyes, ears, skin, gastrointestinal tract and urogenital system. More particularly, this invention relates to substituted ketone drivatives that are useful inhibitors of interleukin-1.beta. converting enzyme (ICE). Interleukin-1.beta. converting enzyme (ICE) has been identified as the enzyme responsible for converting precursor interleukin-1.beta. (IL-1.beta.) to biologically active IL-1.beta..
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.