Peptidyl inhibitors of viral proteases
US5866684A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 1997 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Nov 14, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ; PA1 R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl; PA1 R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; and PA1 R.sup.3 represents hydrogen or lower alkyl; or PA1 R.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy; PA1 R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl; PA1 R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl; PA1 R.sup.6 represents hydrogen or lower alkyl; PA1 R.sup.7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl; PA1 R.sup.8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; and PA1 R.sup.9…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.