Modulation of gene expression through interference with RNA secondary structure
US5866698A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 13, 1994 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Apr 13, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/315
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for modulating the expression of viral genes are provided by selecting a portion of RNA coded by the gene, said RNA portion having subportions forming a secondary structure, and contacting the RNA with oligonucleotide of 6 to 50 which can bind with at least one of said subportions of the RNA. In accordance with the preferred embodiments, oligonucleotides are designed to bind to RNA secondary structures which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are similarly disclosed wherein the oligonucleotides are targeted at the CAR or gag-pol region of HIV RNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.