Adenoviral-mediated gene transfer to adipocytes
US5869037A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 1996 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Jun 26, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for in vivo gene transfer to adipocytes mediated by adenovirus and, in particular, the in vivo transfer of toxic genes as a means of reducing adiposity, as well as the transfer of genes encoding angiogenic substances to induce new blood vessel growth. The present invention also provides for the in vivo gene transfer to adipocytes to supply a source of proteins to be used in the local milieu of the adipocyte tissue or to be secreted and used systemically. Further, the present invention provides for the transfer of the adipocytes to other sites within a host, following adenoviral-mediated transfer of genes to the adipocytes in vivo, to allow for the exploitation of the modified adipocytes as a transferable means for the production of protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.