Modified antibody variable domains
US5869619A · kind A · utility
182Cited by
12References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 23, 1993 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Jun 23, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.