Patent · US Expired

Conformationally locked nucleoside analogues

US5869666A · kind A · utility

4Cited by
1References
16Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 14, 1997
Grant dateFeb 9, 1999
Priority date
Expiry dateMar 14, 2017

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07H21/00
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Conformationally locked 4',6'-cyclopropane-fused carboxylic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine, and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.