Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines

US5871746A · kind A · utility

Assignees

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• INSTITUT PASTEUR · FR
• INSTITUT PASTEUR DE LILLE · FR

Inventors

• Christophe Boutillon · Lille, FR
• Frederic Martinon · Montrouge, FR
• Christian Sergheraert · Hazebrouck, FR
• Remy Magne · Marly-le-Roi, FR
• Helene Gras-Masse · Mérignies, FR
• Elisabeth Gomard · Paris, FR
• Andre Tartar · Pacé, FR
• Jean-Paul Levy · Paris, FR

Key dates

• Filing date: May 31, 1994
• Grant date: Feb 16, 1999
• Expiry date: May 31, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16322
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one antigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups. Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses. DA.