Self-assembling recombinant papillomavirus capsid proteins

US5871998A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Douglas R. Lowy · Washington, US
• John T. Schiller · Silver Spring, US
• Reinhard Kirnbauer · Bethesda, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Feb 16, 1999
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/927
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.