Human til cells expressing recombinant TNF prohormone
US5874077A · kind A · utility
9Cited by
38References
14Claims
0Family size
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Key dates
| Filing date | May 24, 1995 |
| Grant date | Feb 23, 1999 |
| Priority date | — |
| Expiry date | May 24, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/144
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tumor Infiltrating Lymphocyte (TIL) cells transformed with exogenous DNA encoding tumor necrosis factor (TNF) prohormone variants are disclosed. Among such variants are the TNF .gamma. sig construct, which facilitates expression of the mature TNF polypeptide, and the noncleavable cytotoxic prohormone variants TNF.DELTA.(1.fwdarw.12) and TNF(1+12). The transformed TIL cells are useful in antitumor therapy.
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