Induction of neutralizing antibody against viral infection by synergy between virus envelope glycoprotein and peptides corresponding to neutralization epitopes of the glycoprotein
US5876724A · kind A · utility
12Cited by
2References
33Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 28, 1994 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | Jun 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16234
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention comprises a method of enhancing the immunogenicity of an envelope virus glycoprotein in a host organism. The method comprises administering to the host a composition comprising the virus envelope glycoprotein and at least one oligopeptide derived from the amino acid sequence of the envelope glycoprotein, wherein the oligopeptide contains or corresponds to virus-neutralization epitopes. The method and compositions are useful for vaccinating against viruses, such as HIV, SIV, HTLV-I, HTLV-II, or any retrovirus capable of inducing AIDS in its natural host.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.