Heterocyclic compounds, pharmaceutical compositions comprising them and process for the preparation thereof
US5889018A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1995 |
| Grant date | Mar 30, 1999 |
| Priority date | — |
| Expiry date | May 3, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to anxiolytic pharmaceutical compositions comprising as active ingredient 1-sytrylisoquinoline derivatives of general formula (I), wherein PA1 n is 1, 2, 3 or 4; PA1 R may be the same or different and represent(s) hydrogen, lower alkyl, lower alkoxy or hydroxy, or two substituents R attached to adjacent carbon atoms may form together an alkylenedioxy group; PA1 R.sup.1 represents hydrogen or lower alkyl, and PA1 Ar stands for an optionally substituted aryl or heteroaryl, Some of the compounds of general formula (I) is known, but the majority thereof has not so far described in the literature. The invention also encompasses the preparation of the new compounds of general formula (I), which comprises reacting a compound of general formula (II) with an aldehyde or general formula (III) in the presence of a condensing agent or an acidic catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.