Use of TFPI inhibitor for treatment of cancer
US5902582A · kind A · utility
29Cited by
1References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 15, 1996 |
| Grant date | May 11, 1999 |
| Priority date | — |
| Expiry date | Aug 15, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides for the inhibition of the activity of TFPI to prevent TFPI from countering the procoagulant activities associated with many tumors. Inhibition of TFPI activity by the method of the invention facilitates the propensity toward thrombosis in malignancies and therefore promotes tumor cell death. The method of the invention also includes, in addition to the administration of an inhibitor of TFPI, co-administration of an agent capable of inducing or augmenting in the targeted tumor the release or induction of factors that initiate or enhance clotting, such as TF and Factors VIIa and Xa.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.