Reagent useful for synthesizing sulfurized oligonucleotide analogs
US5902881A · kind A · utility
7Cited by
42References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 3, 1997 |
| Grant date | May 11, 1999 |
| Priority date | — |
| Expiry date | Mar 3, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C329/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.