Monoclonal antibody against complexed and non-complexed complexing agents for removing heavy metals from aqueous solutions and for analysis

US5907034A · kind A · utility

Assignee

• Behring Diagnostics GmbH · DE

Inventors

• Klaus Bosslet · Marburg, DE
• Peter Hermentin · Marburg, DE
• Gerhard Seemann · Lahntal, DE

Key dates

• Filing date: May 12, 1995
• Grant date: May 25, 1999
• Expiry date: May 12, 2015

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/84
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to monoclonal antibodies (mAB) which bind to water-soluble complexones such as ethylenediamine tetraacetate (EDTA) or diethylenetriamine pentaacetate (DTPA) with high specificity and avidity and retain their high avidity and specificity for these complexones after complexing of EDTA or DTPA with metal ions. These mAB can therefore be used, e.g. coupled on filters or other supports, for removing toxic heavy metals which are complexed with EDTA or DTPA. Furthermore, these mAB are suitable as components of immunoassays (RIA, ELISA etc.) for the quantitative determination of EDTA or DTPA in aqueous solutions.