Substrate trapping protein tyrosine phosphatases
US5912138A · kind A · utility
7Cited by
2References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 25, 1996 |
| Grant date | Jun 15, 1999 |
| Priority date | — |
| Expiry date | Jul 25, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.