Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
US5914121A · kind A · utility
39Cited by
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6Claims
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Key dates
| Filing date | Feb 12, 1997 |
| Grant date | Jun 22, 1999 |
| Priority date | — |
| Expiry date | Feb 12, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without fibrin glue and implanted into a mammal. This protocol results in the formation of self-maintained human bone which supports hematopoiesis. This model system can be used to screen compounds which inhibit or stimulate bone formation. The marrow stromal fibroblast delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.