E6 associated protein

US5914389A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Jon M. Huibregtse · Watertown, US
• Martin Scheffner · Walldorf, DE
• Peter M. Howley · Wellesley, US

Key dates

• Filing date: Jul 1, 1996
• Grant date: Jun 22, 1999
• Expiry date: Jul 1, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides compositions of isolated and purified E6 Associated Protein and fragments thereof. Also provided are nucleic acid constructs encoding E6 Associated Protein. These compositions may be employed to identify compounds which inhibit binding of high risk HPV E6 to p53. The compositions of the present invention may also be used in methods to detect the presence of high risk HPV in biological samples.