IL-13 receptor specific chimeric proteins

US5919456A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Raj K. Puri · Bethesda, US
• Waldemar Debinski · Winston-Salem, US
• Ira H. Pastan · Potomac, US
• Nicholas Obiri · Gaithersburg, US

Key dates

• Filing date: Mar 21, 1997
• Grant date: Jul 6, 1999
• Expiry date: Mar 21, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides chimeric molecules useful for killing tumor cells bearing IL13 receptor(s) (IL-13R). The molecules comprise a cytotoxic molecule attached to a targeting molecule that specifically binds an IL-13 receptor. Preferred targeting molecules include IL-13 and anti-IL-13R antibodies.