Methods for detecting cervical cancer

US5919624A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Thomas Ried · Bethesda, US
• Gert Auer · Solna, SE
• Evelin Schrock · Rockville, US
• Kerstin Heselmeyer · Edewecht, DE
• Merryn Macville · Kensington, US

Key dates

• Filing date: Jan 10, 1997
• Grant date: Jul 6, 1999
• Expiry date: Jan 10, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/112
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides a method of detecting the presence of invasive cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality which is associated with invasive cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of invasive cervical carcinoma in the subject. The invention also provides a method of detecting the presence of advanced-stage cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality associated with advanced-stage cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of advanced-stage cervical carcinoma in the subject. The invention also provides a method of classifying the progression of dysplastic cervical cells from a non-invasive cervical carcinoma to an invasive cervical carcinoma comprising analyzing the dysplastic cervical cells for the presence of a chromosome abnormality which is associated with invasive cervical carcinoma, and classifying the dysplastic cervical cells having the chromosome abno…