D-homo vitamin D.sub.3 derivatives

US5919986A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Pierre Barbier · Paris, FR
• Franz Bauer · Herzogenaurach, DE
• Peter Mohr · Basel, CH
• Marc Muller · Wolfersdorf, FR
• Wolfgang Pirson · Weil am Rhein, DE

Key dates

• Filing date: Oct 13, 1998
• Grant date: Jul 6, 1999
• Expiry date: Oct 13, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I: ##STR1## wherein the dotted carbon-carbon bond in the D-ring is C--C or C.dbd.C; C(R,R) is CH.sub.2 or C.dbd.CH.sub.2, PA0 R.sup.1 is H, F or OH, PA0 R.sup.2 and R.sup.3 are each independently C.sub.1-4 -alkyl or CF.sub.3, or together with the carbon to which they are bound form C.sub.3-6 -cycloalkyl. are useful in the treatment of vitamin D dependent disorders, such as psoriasis, leukemia; acne and seborrhoic dermatitis; osteoporosis hyperparathyroidism accompanying renal failure; and multiple sclerosis.