Vectors including foreign genes and negative selective markers

US5925345A · kind A · utility

Assignees

• Genetic Therapy, Inc. · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Michael Blaese · Rockville, US
• W. French Anderson · Bethesda, US
• Jeanne R. McLachlin · Watkinsville, US
• Yawen L. Chiang · Potomac, US
• Martin Eglitis · Indianapolis, US

Key dates

• Filing date: May 25, 1995
• Grant date: Jul 20, 1999
• Expiry date: May 25, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/13043
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A vector, in particular a retroviral vector, which includes a heterologous or foreign gene and a gene encoding a negative selective marker. The negative selective marker enables one to kill cells which contain the gene encoding the negative selective marker, when a particular agent is administered to such cells.