Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5929278A · kind A · utility
6Cited by
32References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 19, 1998 |
| Grant date | Jul 27, 1999 |
| Priority date | — |
| Expiry date | May 19, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.