Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules

US5935936A · kind A · utility

Assignees

• Genzyme Corporation · US
• THE UNIVERSITY OF IOWA · US

Inventors

• Allen J. Fasbender · Solon, US
• Michael J. Welsh · Riverside, US
• Craig Siegel · Woburn, US
• Edward R. Lee · Natick, US
• Chau-Dung Chang · Lexington, US
• John Marshall · Milford, US
• Seng H. Cheng · Wellesley, US
• David J. Harris · Lexington, US
• Simon J. Eastman · Hudson, US
• Shirley C. Hubbard · Belmont, US
• Mathieu B. Lane · Cambridge, US
• Eric A. Rowe · Malden, US
• Ronald K. Scheule · Hopkinton, US
• Nelson S. Yew · West Upton, US

Key dates

• Filing date: Jun 3, 1996
• Grant date: Aug 10, 1999
• Expiry date: Jun 3, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/4712
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compositions are provided. Typically, the compositions comprise one or more neutral co-lipids and also a cationic amphiphile. Therapeutic compositions are prepared according to the practice of the invention by contacting a therapeutically active molecule with a dispersion of neutral co-lipid(s) and amphiphile(s).