Nucleotide analog composition and synthesis method
US5935946A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 25, 1997 |
| Grant date | Aug 10, 1999 |
| Priority date | — |
| Expiry date | Jul 25, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65616
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.