Cationic amphiphile compositions for intracellular delivery of therapeutic molecules

US5939401A · kind A · utility

Assignee

• Genzyme Corporation · US

Inventors

• John Marshall · Milford, US
• David J. Harris · Lexington, US
• Edward R. Lee · Natick, US
• Craig Siegel · Woburn, US
• Simon J. Eastman · Hudson, US
• Chau-Dung Chang · Lexington, US
• Ronald K. Scheule · Hopkinton, US
• Seng H. Cheng · Wellesley, US

Key dates

• Filing date: Jul 15, 1996
• Grant date: Aug 17, 1999
• Expiry date: Jul 15, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.