Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
US5948898A · kind A · utility
5Cited by
8References
4Claims
0Family size
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Key dates
| Filing date | Feb 14, 1996 |
| Grant date | Sep 7, 1999 |
| Priority date | — |
| Expiry date | Feb 14, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3533
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.