Oligonucleotides having a conserved G4 core sequence
US5952490A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 12, 1995 |
| Grant date | Sep 14, 1999 |
| Priority date | — |
| Expiry date | Jun 12, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/346
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modified oligonucleotides having a conserved G.sub.4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A.sub.2 or to modulate the telomere length of a chromosome are provided. G.sub.4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnosis and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A.sub.2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to plat a role in the aging process of a cell and in control of malignant cell growth.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.