High affinity nucleic acid ligands containing modified nucleotides
US5958691A · kind A · utility
185Cited by
5References
24Claims
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Key dates
| Filing date | Aug 25, 1997 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | Aug 25, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/976
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2'- and 5-position. Specific 2-OH and 2'-NH.sub.2 modified RNA ligands to thrombin are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.