Phenyl-substituted 5H-thiazolo3,2-A!pyrimidine derivative glutamate receptor antagonists

US5958931A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Geo Adam · Schopfheim, DE
• Sabine Kolczewski · Lörrach, DE
• Vincent Mutel · Mulhouse, FR
• Jurgen Wichmann · Steinen, DE
• Thomas Woltering · Freiburg (Elbe), DE

Key dates

• Filing date: Jul 14, 1998
• Grant date: Sep 28, 1999
• Expiry date: Jul 14, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is concerned with compounds of the general formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, phenyl or benzyl, PA1 R.sup.2 is lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n N(R.sup.13)(R.sup.14), --(CH.sub.2).sub.n N(R.sup.13)(R.sup.14) or --N(R.sup.15)(CH.sub.2).sub.n N(R.sup.13)(R.sup.14), PA1 R.sup.3 -R.sup.12 are hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano, --N(R.sup.13).sub.2, phenyl, phenyloxy, benzyl or benzyloxy, or PA1 R.sup.6 and R.sup.7 together are a benzene ring, PA1 R.sup.13 -R.sup.15 are hydrogen, lower alkyl or cycloalkyl and PA1 n is 1-5, as well as their pharmaceutically acceptable salts.