Use of 4-phenyl-3,6-dihydro-2H-pyridyl derivatives

US5962472A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Anne Bourson · Mulhouse, FR
• Gunther Fischer · Lörrach, DE
• Marie-Paule Heitz Neidhart · Rixheim, FR
• Vincent Mutel · Mulhouse, FR
• Gerhard Trube · Rheinfelden (Baden), DE

Key dates

• Filing date: Mar 7, 1997
• Grant date: Oct 5, 1999
• Expiry date: Mar 7, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of compounds of general formula ##STR1## wherein R.sup.1 is hydrogen, halogen, lower alkyl or lower alkoxy; PA0 R.sup.2 is hydrogen; PA0 R.sup.3 is hydrogen, amino, ureido, lower alkylcarbonyl, lower alkyl-sulfonylamino, lower alkylcarbamoyl, carbamoyl, lower alkyloxycarbamoyl, lower alkylamino or PA0 R.sup.2 and R.sup.3 taken together are --(CH.sub.2).sub.m -- PA0 X is methylene, hydroxymethylene, lower alkoxymethylene or carbonyl, PA0 n is 0, 1 or 2 and PA0 m is 3 or 4 as well as pharmaceutically acceptable salts for the control or treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers.