Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
US5962674A · kind A · utility
60Cited by
1References
2Claims
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Key dates
| Filing date | Feb 26, 1996 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Feb 26, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides new reagents and an improved process for synthesizing oligonucleotides that contain methylphosphonate internucleoside linkages. The reagents and process utilize a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.