Vectors and methods for gene transfer to cells
US5965541A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 28, 1995 |
| Grant date | Oct 12, 1999 |
| Priority date | — |
| Expiry date | Nov 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/6018
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus coat protein according to the invention is able to direct entry into cells of a vector comprising the coat protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus coat protein rather than the chimeric adenovirus coat protein. The chimeric coat protein preferably is a fiber, hexon, or penton protein. The present invention also provides an adenoviral vector that comprises the chimeric adenovirus coat protein, as well as methods of constructing and using such a vector.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.