Backbone modified oligonucleotide analogues
US5965721A · kind A · utility
134Cited by
9References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 11, 1996 |
| Grant date | Oct 12, 1999 |
| Priority date | — |
| Expiry date | Dec 11, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.