Patent · US Expired

Peptide plasminogen activators

US5976530A · kind A · utility

1Cited by

8References

14Claims

0Family size

Assignees

Chiron Corporation · US
Hoechst Marion Roussel Deutschland GmbH · DE

Inventors

Nancy L. Haigwood · Oakland, US
Guy Mullenbach · Oakland, US
Ernst-Guenter Afting · Marburg, DE
Eric-Paul Paques · Marburg, DE

Key dates

Filing date	Feb 13, 1997
Grant date	Nov 2, 1999
Priority date	—
Expiry date	Feb 13, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21069
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibition by plasminogen activator inhibitor, fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying one or more loci by deletions or substitutions. One or both of the N- or C-termini may be modified.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.