Potent peptide for stimulation of cytotoxic T lymphocytes specific for the HIV-1 envelope

US5976541A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Jay A. Berzofsky · Bethesda, US
• Toshiyuki Taskeshita · Rockville, US
• Mutsunori Shirai · Rockville, US
• C. David Pendleton · Bethesda, US
• Steven Kozlowski · Washington, US
• David Harvey Margulies · Bethesda, US

Key dates

• Filing date: Mar 6, 1992
• Grant date: Nov 2, 1999
• Expiry date: Mar 6, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides having high activity in the eliciting of a cytotoxic T lymphocyte response to the HIV-1 envelope glycoprotein gpl60 are described. The activation of 12-15 residue peptides by proteolytic degradation to shorter peptides is shown as are general techniques for characterizing such activation processes.