Screening assays for compounds that cause apoptosis and related compounds

US5985829A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Curtis C. Harris · Bethesda, US
• Xin Wang · Beijing, CN
• Jan H. J. Hoeijmakers · Zevenhuizen, NL

Key dates

• Filing date: Jul 1, 1996
• Grant date: Nov 16, 1999
• Expiry date: Jul 1, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.