Peptide analogs as irreversible interleukin-1.beta. protease inhibitors

US5985838A · kind A · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Roland E. Dolle · King of Prussia, US
• Irennegbe Kelly Osifo · Norristown, US
• Stanley J. Schmidt · Chester Springs, US
• Denton W. Hoyer · West Haven, US
• Tina Morgan Ross · Limerick, US
• Prasad V. Chaturvedula · Exton, US
• Catherine P. Prouty · Doylestown, US
• Mohamed M. A. Awad · Westerly, US
• Joseph M. Salvino · Chester Springs, US
• James Rinker · Reading, US
• Eric P. Lodge · Glendale, US
• Jasbir Singh · Gilbertsville, US
• Mark A. Ator · Paoli, US

Key dates

• Filing date: Jul 10, 1996
• Grant date: Nov 16, 1999
• Expiry date: Jul 10, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06191
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for inhi.beta.iting interleukin-1.beta. protease activity, the compounds .alpha.-substituted methyl ketones having the formula (I) set forth herein. These compounds are inhibitors of IL-1.beta. converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.