Peptides that bind to the erythropoietin receptor

US5986047A · kind A · utility

Assignee

• Affymax Technologies N.V. · NL

Inventors

• Nicholas Wrighton · Palo Alto, US
• William J. Dower · Menlo Park, US
• Ray S. Chang · Colma, US
• Arun K. Kashyap · Newark, US

Key dates

• Filing date: Mar 28, 1997
• Grant date: Nov 16, 1999
• Expiry date: Mar 28, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3X4X5GPX6TWX7X8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X3 is C; X4 is R, H, L, or W; X.sub.5 is M, F, or I; X6 is independently selected from any one of the 20 genetically coded L-amino acids; X7 is D, E, I, L, or V; and X8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.