Vitronectin receptor antagonists, their preparation and their use

US5990145A · kind A · utility

Assignees

• Hoechst GmbH · DE
• Genentech, Inc. · US

Inventors

• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE
• Anuschirwan Peyman · Kelkheim, DE
• Karlheinz Scheunemann · Liederbach, DE
• Jean-Marie Ruxer · Paris, FR
• Denis Carniato · Marcoussis, FR
• Jean-Michel Lefrancois · Livry-Gargan, FR
• Thomas Gadek · Oakland, US
• Robert McDowell · San Francisco, US

Key dates

• Filing date: Dec 22, 1997
• Grant date: Nov 23, 1999
• Expiry date: Dec 22, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formula I, EQU A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.