"Kallikrein-inhibiting ""Kunitz Domain"" proteins and analogues thereof"
US5994125A · kind A · utility
44Cited by
12References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 17, 1998 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Aug 17, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Proteins are disclosed that are homologous to bovine pancreatic trypsin inhibitor (BPTI) Kunitz domains, and especially proteins that are homologous to lipoprotein-associated coagulation inhibitor (LACI) Kunitz domains, which inhibit one or more plasma and/or tissue kallikreins, and uses of such proteins in therapeutic and diagnostic methods also are disclosed. In particular, Kunitz domains derived from Kunitz domains of human origin and especially to the first Kunitz domain of LACI are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.