Dihomo-seco-cholestanes
US5994569A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 1998 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Jul 14, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyunsaturated 24a,24b-dihomo-9,10-secocholestane derivatives of formula ##STR1## wherein A is a single or double bond, PA1 B.sup.1 and B.sup.2 are each independently CH.dbd.CH or C.tbd.C, PA1 T is CH.sub.2 or CH.sub.2 CH.sub.2, PA1 X is --CH.sub.2 -- or >C.dbd.CH.sub.2, PA1 R.sup.1 is H, F or OH, PA1 R.sup.2 and R.sup.3 are each independently lower alkyl or CF.sub.3, or PA1 C(R.sup.2,R.sup.3) is C.sub.3-6 -cycloalkyl, are useful in the treatment or prevention of vitamin D dependent disorders and of IL-12-dependent autoimmune diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis, leukemia, osteoporosis, hyperparathyroidism accompanying renal failure, multiple sclerosis, transplant rejection, graft vs. host disease, rheumatoid arthritis, insulin-dependent diabetes mellitus, inflammatory bowel disease, septic shock and allergic encephalomyelitis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.