In vitro activation of cytotoxic T cells
US6001365A · kind A · utility
21Cited by
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1Claims
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Assignee
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Key dates
| Filing date | Jun 24, 1998 |
| Grant date | Dec 14, 1999 |
| Priority date | — |
| Expiry date | Jun 24, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2239/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the treatment of a variety of conditions, including cancer, tumors or neoplasias, as well as viral, retroviral, autoimmune, and autoimmune-type diseases. The present invention also relates to vectors, cell lines, recombinant DNA molecules encoding human .beta.2 microglobulin or Class I MHC molecules in soluble and insoluble form, and methods of producing same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.